|
|
2008 |
|
| Oct 21, 2008 |
|
US Patent No 7,439,345
Supramolecular pairing system, its preparation and use |
| |
| Sep 16, 2008 |
|
US Patent No. 7,425,308
Systems for the active electronic control of biological reactions |
| |
| Jun 3, 2008 |
|
US Patent No. 7,381,818
Fluorescent probes containing 5'-minor groove binder, fluorophore and quenching moieties and methods of use thereof |
| |
| May 6, 2008 |
|
US Patent No. 7,368,549
Tm leveling compositions |
| |
| Mar 25, 2008 |
|
US Patent No. 7,348,146
Single nucleotide polymorphism analysis of highly polymorphic target sequences |
| |
| Feb 12, 2008 |
|
US Patent No. 7,329,501
Interalpha trypsin inhibitor biopolymer markers indicative of insulin resistance |
| |
| Jan 15, 2008 |
|
US Patent No. 7,319,022
Amplification methods |
| |
| Jan 1, 2008 |
|
US Patent No. 7,314,762
Apolipoprotein biopolymer markers indicative of insulin resistance |
| |
| Jan 1, 2008 |
|
US Patent No. 7,314,717
Biopolymer marker indicative of disease state having a molecular weight of 1562 daltons |
| |
| Jan 1, 2008 |
|
US Patent No. 7,314,708
Method and apparatus for electronic synthesis of molecular structures |
| |
| Jan 1, 2008 |
|
US Patent No. 7,314,542
Methods and materials for optimization of electronic transportation and hybridization reactions |
| |
2007 |
|
| Nov 27, 2007 |
|
US Patent No. 7,300,757
Electronic systems and component devices for macroscopic and microscopic molecular biological reaction, analyses, and diagnostics |
| |
| Nov 20, 2007 |
|
US Patent No. 7,297,495
Hybridization-triggered fluorescent detection of nucleic acids |
| |
| Nov 13, 2007 |
|
US Patent No. 7,294,688
Biopolymer marker indicative of disease state having a molecular weight of 1348 daltons |
| |
| Sep 18, 2007 |
|
US Patent No. 7,270,850
Mesoporous permeation layers for use on active electronic matrix devices |
| |
| Sep 11, 2007 |
|
US Patent No. 7,267,751
Programmable multiplexed active biologic array |
| |
| Sep 4, 2007 |
|
US Patent No. RE39,816
Conjunctive analysis of biological marker expression for predicting cardiac mortality |
| |
| Aug 14, 2007 |
|
US Patent No. 7,256,053
Diagnostic device for analyte detection |
| |
| Aug 7, 2007 |
|
US Patent No. 7,252,940
Abasic site endonuclease assay |
| |
| Jul 10, 2007 |
|
US Patent No. 7,241,419
Circuits for the control of output current in an electronic device for performing active biological operations |
| |
| Apr 17, 2007 |
|
US Patent No. 7,205,105
Real-time linear detection probes: sensitive 5'-minor groove binder-containing probes for PCR analysis |
| |
| Mar 6, 2007 |
|
US Patent No. 7,186,813
Biomolecules having multiple attachment moieties for binding to a substrate surface |
| |
| Feb 20, 2007 |
|
US Patent No. 7,179,610
Complement C3 precursor biopolymer markers indicative of insulin resistance |
| |
| Feb 20, 2007 |
|
US Patent No. 7,179,606
IG heavy chain, IG kappa, IG lambda biopolymer markers predictive of Alzheimer's disease |
| |
| Feb 20, 2007 |
|
US Patent No. 7,179,605
Fibronectin precursor biopolymer markers indicative of Alzheimer's disease |
| |
| Feb 6, 2007 |
|
US Patent No. 7,172,896
Integrated protable biological detection system |
| |
| Feb 6, 2007 |
|
US Patent No. 7,172,864
Methods for electronically-controlled enzymatic reactions |
| |
2006 |
|
| Dec 26, 2006 |
|
US Patent No. 7,153,955
Pentopyranosyl nucleic acid arrays, and uses thereof |
| |
| Dec 19, 2006 |
|
US Patent No. 7,150,997
Multiplexed active biologic array |
| |
| Nov 14, 2006 |
|
US Patent No. 7,135,297
Protein biopolymer markers indicative of insulin resistance |
| |
| Nov 14, 2006 |
|
US Patent No. 7,135,283
Topoisomerase type II gene polymorphisms and their use in identifying drug resistance and pathogenic strains of microorganisms |
| |
| Nov 7, 2006 |
|
US Patent No. 7,132,244
Betaine/GABA transport protein biopolymer marker indicative of insulin resistance |
| |
| Oct 31, 2006 |
|
US Patent No. 7,129,229
Hydrazide building blocks and hydrazide modified biomolecules |
| |
| Oct 24, 2006 |
|
US Patent No. 7,125,678
Protein biopolymer markers predictive of type II diabetes |
| |
| Oct 17, 2006 |
|
US Patent No. 7,122,327
Biopolymer markers indicative of type II diabetes |
| |
| Sep 26, 2006 |
|
US Patent No. 7,112,684
Compounds and methods for fluorescent labeling |
| |
| Sep 5, 2006 |
|
US Patent No. 7,101,717
Addressable biologic electrode array |
| |
| Sep 5, 2006 |
|
US Patent No. 7,101,680
Method for detecting the presence of monomeric brain associated human glutamine synthetase |
| |
| Sep 5, 2006 |
|
US Patent No. 7,101,661
Apparatus for active programmable matrix devices |
| |
| Aug 29, 2006 |
|
US Patent No. 7,097,989
Complement C4 precursor biopolymer markers predictive of type II diabetes |
| |
| Aug 22, 2006 |
|
US Patent No. 7,094,549
Fibronectin biopolymer marker indicative of insulin resistance |
| |
| Aug 8, 2006 |
|
US Patent No. 7,087,435
Biopolymer maker indicative of disease state having a molecular weight of 2753 daltons |
| |
| Jul 11, 2006 |
|
US Patent No. 7,074,576
Protein biopolymer markers indicative of Alzheimer's disease |
| |
| Jul 4, 2006 |
|
US Patent No. 7,070,961
Electronically mediated nucleic acid amplification in NASBA |
| |
| Jul 4, 2006 |
|
US Patent No. 7,070,945
Process for determining the presence of monomeric brain associated human glutamine synthetase in patients exhibiting mild cognitive impairment |
| |
| Jun 13, 2006 |
|
US Patent No. 7,060,224
Methods for electronic, homogeneous assembly and fabrication of devices |
| |
| May 29, 2006 |
|
US Patent No. 7,052,849
Protein biopolymer markers predictive of insulin resistance |
| |
| May 23, 2006 |
|
US Patent No. 7,049,397
Biopolymer marker indicative of disease state having a molecular weight of 1211 daltons |
| |
| May 16, 2006 |
|
US Patent No. 7,045,610
Modified oligonucleotides for mismatch discrimination |
| |
| May 16, 2006 |
|
US Patent No. 7,045,097
Biologic electrode array with integrated optical detector |
| |
| Apr 11, 2006 |
|
US Patent No. 7,026,129
IG lambda biopolymer markers predictive of Alzheimers disease |
| |
| Mar 21, 2006 |
|
US Patent No. 7,015,004
Inter-alpha trypsin inhibitor biopolymer marker indicative of insulin resistance |
| |
| Mar 21, 2006 |
|
US Patent No. 7,014,854
Method for retarding or precluding Alzheimer's dementia |
| |
| Feb 14, 2006 |
|
US Patent No. 6,998,243
Biopolymer marker indicative of disease state having a molecular weight of 1793 daltons |
| |
| Jan 24, 2006 |
|
US Patent No. 6,989,086
Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis |
| |
2005 |
|
| Dec 6, 2005 |
|
US Patent No. 7,972,339
Compounds and methods for fluorescent labeling |
| |
| Dec 6, 2005 |
|
US Patent No. 6,792,328
Non-aggregating non-quenching oligomer comprising nucleotide analogs |
| |
| Nov 8, 2005 |
|
US Patent No. 6,962,991
Process for the synthesis of pyrazolopyrimidine |
| |
| Nov 1, 2005 |
|
US Patent No. 6,960,298
Mesoporous permeation layers for use on active electronic matrix devices |
| |
| Oct 4, 2005 |
|
US Patent No. 6,951,930
Hybridization-triggered fluorescent detection of nucleic acids |
| |
| Sep 27, 2005 |
|
US Patent No. 6,949,367
Modified oligonucleotides for mismatch discrimination |
| |
| Sep 13, 2005 |
|
US Patent No. 6,942,778
Microstructure apparatus and method for separating differently charged molecules using an applied electric field |
| |
| Jun 28, 2005 |
|
US Patent No. 6,911,310
Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system |
| |
| May 17, 2005 |
|
US Patent No. 6,893,822
Enzymatic modification of a nucleic acid-synthetic binding unit conjugate |
| |
| May 10, 2005 |
|
US Patent No. 6,891,154
Amino acid sequence pattern matching |
| |
| May 10, 2005 |
|
US Patent No. 6,890,763
Biopolymer maker indicative of disease state having a molecular weight of 1350 daltons |
| |
| May 10, 2005 |
|
US Patent No. 6,890,722
HP biopolymer markers predictive of insulin resistance |
| |
| May 3, 2005 |
|
US Patent No. 6,887,362
Dielectrophoretic separation and immunoassay methods on active electronic matrix devices |
| |
| Apr 26, 2005 |
|
US Patent No. 6,884,584
Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders |
| |
| Mar 15, 2005 |
|
US Patent No. 6,867,048
Multiplexed active biologic array |
| |
| Mar 8, 2005 |
|
US Patent No. 6,864,071
Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification an bioelectronic chip technology |
| |
| Jan 4, 2005 |
|
US Patent No. 6,838,053
Platinum silicide permeation layer device with microlocaions |
| |
2004 |
|
| Nov 30, 2004 |
|
US Patent No. 6,824,740
Apparatus for active biological sample preparation |
| |
| Nov 23, 2004 |
|
US Patent No. 6,821,729
Devices for molecular biological analysis and diagnostics including waveguides |
| |
| Sep 14, 2004 |
|
US Patent No. 6,790,945
Fluorescent quenching detection reagents and methods |
| |
| Aug 24, 2004 |
|
US Patent No. 6,780,584
Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics |
| |
| Jun 22, 2004 |
|
US Patent No. 6,753,148
Methods and apparatus for detecting variants utilizing base stacking |
| |
| Apr 27, 2004 |
|
US Patent No. 6,727,356
Fluorescent quenching detection reagents and methods |
| |
| Apr 27, 2004 |
|
US Patent No. 6,726,880
Electronic device for performing active biological operations and method of using same |
| |
| Mar 16, 2004 |
|
US Patent No. 6,706,473
Systems and devices for photoelectronic transport and hybridization of oligonucleotides |
| |
| Mar 2, 2004 |
|
US Patent No. 6,699,978
Linker nucleoside, and production and use of the same |
| |
| Mar 2, 2004 |
|
US Patent No. 6,699,975
Fluorescent quenching detection reagents and methods |
| |
| Feb 24, 2004 |
|
US Patent No. 6,696,555
3'-Desoxypentopyranosyl nucleic acid, its production and its use |
| |
| Feb 10, 2004 |
|
US Patent No. 6,689,884
Supramolecular pairing system, its preparation and use |
| |
| Feb 3, 2004 |
|
US Patent No. RE38,416
Cross-linking oligonucleotides |
| |
| Jan 27, 2004 |
|
US Patent No. 6,683,173
Tm Leveling Methods |
| |
| Jan 27, 2004 |
|
US Patent No. 6,682,936
Addressable biologic electrode array |
| |
2003 |
|
| Dec 9, 2003 |
|
US Patent No. 6,660,845
Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof |
| |
| Nov 25, 2003 |
|
US Patent No. 6,653,473
Fluorescent quenching detection reagents and methods |
| |
| Nov 25, 2003 |
|
US Patent No. 6,652,808
Methods for the electronic assembly and fabrication of devices |
| |
| Oct 28, 2003 |
|
US Patent No. 6,638,482
Reconfigurable detection and analysis apparatus and method |
| |
| Sep 30, 2003 |
|
US Patent No. 6,626,417
Microfluidic valve and microactuator for a microvalve |
| |
| Sep 2, 2003 |
|
US Patent No. 6,613,894
Method for producing a pyranosyl nucleic acid conjugate |
| |
| Aug 19, 2003 |
|
US Patent No. 6,608,186
Pyranosyl nucleic acid conjugates |
| |
| Jul 8, 2003 |
|
US Patent No. 6,589,742
Multiplex amplification and separation of nucleic acid sequences on a bioelectronic microchip using asymmetric structures |
| |
| Jun 24, 2003 |
|
US Patent No. 6,582,660
Control system for active programmable electronic microbiology system |
| |
| May 27, 2003 |
|
US Patent No. 6,569,382
Method for the electronic assembly and fabrication of devices |
| |
| Apr 15, 2003 |
|
US Patent No. 6,548,652
Attachment of oligonucleotides to solid supports through schiff base type linkages for capture and detection of nucleic acids |
| |
| Apr 8, 2003 |
|
US Patent No. 6,545,134
Method for the production of pentopyranosyl nucleosides |
| |
| Apr 1, 2003 |
|
US Patent No. 6,540,961
Multicomponent devices for molecular biological analysis and diagnostics |
| |
| Mar 11, 2003 |
|
US Patent No. 6,531,302
Anchored strand displacement amplification on an electronically addressable microchip |
| |
| Feb 25, 2003 |
|
US Patent No. 6,524,517
Methods for molding and grafting highly uniform polymer layers onto electronic microchips |
| |
| Feb 11, 2003 |
|
US Patent No. 6,518,022
Method for enhancing the hybridization efficiency of target nucleic acids using a self-addressable, self-assembling microelectronic device |
| |
| Jan 14, 2003 |
|
US Patent No. 6,506,896
Use of a pentopyranosyl nucleoside for producing an electronic component, and conjugates of said pentopyranosyl nucleoside |
| |
2002 |
|
| Dec 10, 2002 |
|
US Patent No. 6,492,346
Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders |
| |
| Dec 10, 2002 |
|
US Patent No. 6,492,122
Quantitative analysis methods on active electronic microarrays |
| |
| Dec 3, 2002 |
|
US Patent No. 6,488,832
Array based electrophoretic system for the analysis of multiple biological samples |
| |
| Nov 26, 2002 |
|
US Patent No. 6,486,308
Covalently linked oligonucleotide minor groove binder conjugates |
| |
| Nov 26, 2002 |
|
US Patent No. 6,485,906
Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination |
| |
| Oct 29, 2002 |
|
US Patent No. 6,472,153
Hybridization-triggered fluorescent detection of nucleic acids |
| |
| Oct 22, 2002 |
|
US Patent No. 6,468,742
Methods for determination of single nucleic acid polymorphisms using bioelectronic microchip |
| |
| Aug 27, 2002 |
|
US Patent No. 6,441,159
Attachment of oligonucleotides to solid supports through schiff base type linkages for capture and detection of nucleic acids |
| |
| Jul 30, 2002 |
|
US Patent No. 6,426,408
Covalently linked oligonucleotide minor groove binder conjugates |
| |
| Jul 23, 2002 |
|
US Patent No. 6,423,271
Laminated assembly for active bioelectronic devices |
| |
| Jul 9, 2002 |
|
US Patent No. 6,416,953
Hybridization of polynucleotides conjugated with chromophores and fluorophoes to generate donor-to-donor energy transfer system |
| |
| Jun 11, 2002 |
|
US Patent No. 6,403,367
Integrated portable biological detection system |
| |
| May 28, 2002 |
|
US Patent No. 6,395,493
Methods and apparatus for determination of length polymorphisms in DNA |
| |
| May 7, 2002 |
|
US Patent No. 6,385,080
DNA optical storage device using forster energy transfer mechanism |
| |
| Apr 30, 2002 |
|
US Patent No. 6,379,897
Methods for gene expression monitoring on electronic microarrays |
| |
| Apr 23, 2002 |
|
US Patent No. 6,375,899
Electrophoretic buss for transport of charged materials in a multi-chamber system |
| |
| Jan 15, 2002 |
|
US Patent No. 6,339,147
Attachment of oligonucleotides to solid supports through schiff base type linkages for capture and detection of nucleic acids |
| |
2001 |
|
| Dec 18, 2001 |
|
US Patent No. 6,331,274
Advanced active circuits and devices for molecular biological analysis and diagnostics |
| |
| Dec 4, 2001 |
|
US Patent No. 6,326,173
Electronically Mediated Nucleic Acid Amplification in NASBA |
| |
| Nov 20, 2001 |
|
US Patent No. 6,319,472
System including functionally separated regions in electrophoretic system |
| |
| Nov 13, 2001 |
|
US Patent No. 6,315,953
Devices for molecular biological analysis and diagnostics including waveguides |
| |
| Nov 6, 2001 |
|
US Patent No. 6,312,894
Improved hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders |
| |
| Oct 30, 2001 |
|
US Patent No. 6,309,833
Multiplex amplification and separation of nucleic acid sequences on a bioelectronic microchip using asymmetric structures |
| |
| Oct 30, 2001 |
|
US Patent No. 6,309,602
Stacked, reconfigurable system for electrophoretic transport of charged materials |
| |
| Oct 30, 2001 |
|
US Patent No. 6,309,601
Scanning optical detection system |
| |
| Oct 23, 2001 |
|
US Patent No. 6,306,348
Inorganic permeation layer for micro-electric device |
| |
| Oct 16, 2001 |
|
US Patent No. 6,303,082
Permeation layer attachment chemistry and method |
| |
| Sep 11, 2001 |
|
US Patent No. 6,287,517
Laminated assembly for active bioelectronic devices |
| |
| Sep 4, 2001 |
|
US Patent No. 6,284,117
Apparatus and method for removing small molecules and ions from Low Volume Biological Samples |
| |
| Aug 28, 2001 |
|
US Patent No. 6,280,590
Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis |
| |
| Jul 10, 2001 |
|
US Patent No. 6,258,606
Multiplexed active biologic array |
| |
| Jul 3, 2001 |
|
US Patent No. 6,254,827
Methods for fabricating multi-component devices for molecular biological analysis and diagnostics |
| |
| Jun 19, 2001 |
|
US Patent No. 6,249,784
System and method for searching and processing databases comprising named annotated text strings |
| |
| Jun 12, 2001 |
|
US Patent No. 6,245,508
Method for fingerprinting utilizing an electronically addressable array |
| |
| May 29, 2001 |
|
US Patent No. 6,238,868
Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification and bioelectronic chip technology |
| |
| May 29, 2001 |
|
US Patent No. 6,238,624
Methods for transport in molecular biological analysis and diagnostics |
| |
| May 1, 2001 |
|
US Patent No. 6,225,059
Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics |
| |
| Mar 27, 2001 |
|
US Patent No. 6,207,373
Methods for determining nature of repeat units In DNA |
| |
2000 |
|
| Dec 22, 2000 |
|
US Patent No. 6,162,603
Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system |
| |
| Oct 10, 2000 |
|
US Patent No. 6,129,828
Apparatus and methods for active biological sample preparation |
| |
| Oct 3, 2000 |
|
US Patent No. 6,127,121
Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination |
| |
| Aug 8, 2000 |
|
US Patent No. 6,099,803
Advanced active electronic devices for molecular biological analysis and diagnostics |
| |
| Jul 4, 2000 |
|
US Patent No. 6,084,102
Covalently linked oligonucleotide minor groove binder conjugates |
| |
| Jun 6, 2000 |
|
US Patent No. 6,071,394
Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis |
| |
| May 30, 2000 |
|
US Patent No. 6,068,818
Multicomponent devices for molecular biological analysis and diagnostics |
| |
| May 23, 2000 |
|
US Patent No. 6,067,246
Method for writing data to and reading multiple bit data words from a DNA optical storage device |
| |
| Apr 18, 2000 |
|
US Patent No. 6,051,380
Methods and procedures for molecular biological analysis and diagnostics |
| |
| Apr 11, 2000 |
|
US Patent No. 6,048,690
Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis |
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1999 |
|
| Oct 12, 1999 |
|
US Patent No. 5,965,452
Multiplexed active biologic array |
| |
| Jul 27, 1999 |
|
US Patent No. 5,929,208
Methods for electronic synthesis of polymers |
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| Jun 15, 1999 |
|
US Patent No. 5,912,340
Selective binding complementary oligonucleotides |
| |
| Jan 25, 1999 |
|
US Patent No. 6,017,696
Methods for electronic stringency control for molecular biological analysis and diagnostics |
| |
| Jan 11, 1999 |
|
US Patent No. 6,013,166
Method for reducing the linear dimension necessary for high resolution electrophoretic separation |
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1998 |
|
| Dec 15, 1998 |
|
US Patent No. 5,849,489
Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system |
| |
| Dec 15, 1998 |
|
US Patent No. 5,849,486
Methods for hybridization analysis utilizing electronically controlled hybridization |
| |
| Nov 10, 1998 |
|
US Patent No. 5,835,404
DNA optical storage device utilizing non-radiative energy transfer |
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| Sep 1, 1998 |
|
US Patent No. 5,801,155
Oligonucleotide minor groove binder conjugates |
| |
| Jul 28, 1998 |
|
US Patent No. 5,787,032
Deoxyribonucleic acid (DNA) optical storage using non-radiative energy transfer between a donor group, an acceptor group and a quencher group |
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1997 |
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| May 27, 1997 |
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US Patent No. 5,632,957
Molecular biological diagnostic systems including electrodes |
| |
| Feb 25, 1997 |
|
US Patent No. 5,605,662
Active programmable electronic devices for molecular biological analysis and diagnostics |
| |
1996 |
|
| Oct 15, 1996 |
|
US Patent No. 5,565,322
Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system |
| |
| Jul 2, 1996 |
|
US Patent No. 5,532,129
Self-organizing molecular photonic structures based on chromophore and fluorophore containing polynucleotides and methods of their use |
| |
| Apr 29, 1996 |
|
US Patent No. 5,512,667
Trifunctional intermediates for preparing 3'-tailed oligonucleotides |
| |
1995 |
|
| May 30, 1995 |
|
US Patent No. 5,419,966
Solid support for synthesis of 3'-tailed oligonucleotides |
| |
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